Background: Melanoma is a type of tumor that originates from melanocytes, the pigment-producing cells in the skin. To ensure a clear surgical margin, it is crucial to employ the appropriate surgical technique promptly. Mohs micrographic surgery is one such technique. This study examines the outcomes of patients with melanoma who underwent delayed Mohs surgery. Methods: This retrospective cross-sectional study included 30 patients who underwent delayed Mohs surgery. We collected demographic data, including age and sex, as well as clinical information such as the age of melanoma onset, the location and size of the lesion, disease stage, lesion characteristics before Mohs surgery, recurrence rate, mortality rate, and the interval between Mohs surgery and disease recurrence. Data were analyzed using SPSS software. Results: Among the patients, 73. 3% were women. The mean age of patients at the time of the study was 39. 1 ± 8. 55 years, while the mean age at the time of diagnosis was 35. 5 ± 7. 8 years. The recurrence rate was 0. 77 ± 0. 5, and the number of Mohs procedures performed per patient was 1. 4 ± 0. 56. Additionally, 13. 3% of the patients had died by the time of the study. The findings of the present study demonstrated that recurrence is significantly associated with the stage of the disease. Conclusion: The findings of this study indicate that the recurrence of melanoma is significantly associated with the stage of the disease, while the location of the lesion does not appear to have a significant impact. Additionally, the recurrence rate and mortality associated with melanoma in patients examined in this study are higher than those reported in previous research. This discrepancy may be attributed to the relationship between these factors and the disease stage. Furthermore, it is possible that the higher recurrence rates observed in this study compared to others may be due to the effectiveness of classical Mohs surgery over delayed Mohs surgery, making it a more suitable option for patients. However, further research is necessary to validate the findings of this study.

Background: Among non-melanoma skin cancers (NMSC), Basal cell carcinoma (BCC) is one of the most common. Objectives: We endeavored to assess the recurrence rate of BCC after surgery and compare tumors recurrence based on different aspects. Methods: This was a retrospective and observational study which was analyzed medical records of 154 patients who had Mohs micrographic surgery (MMS) from March 2013 to February 2017 in two clinical centers. For finding if the clinical characteristics of the patients have related to tumoral recurrence, we gathered them, including gender and age of the patient, tumor size, site, and its histological type plus the existence of ulcer in malignancy. Data were analyzed using SPSS 22 statistical software. Statistical difference between proportions was determined by  2 analysis. Results: The majority of patients (74%) were female (57%) older than 60 years old. Most tumors, based on the histopathological diagnosis, were Infiltrating (43. 5%) and nodular and infiltrating (40. 3%), respectively. The mean tumor size was 1. 81 cm and most of them(74%) were larger than 1 cm. The tumor site was mostly in the nasal (56. 5%) followed by the cheek (11%). Most patients (96. 8%) had one lesion. The recurrence rate was 1. 9%. The mean interval between surgeries to recurrence was 13 months. There was no significant difference between recurrence rate and age, sex, tumor type in terms of clinical diagnosis, tumor location, tumor size, number of lesions, and type of tumor (P < 0. 05). Conclusions: the rate of recurrence of BCC in patients treated with MMS is low (1. 9%). We recommend the utilization of the MMS technique for the treatment of BCC.

Introduction: Modified Mohs" Surgery (MMS) has not ever been performed for management of skin cancers in Iran. The aim of this study was evaluation of the efficacy of MMS in recurrence, metastasis rate and cosmetic results. Methods: Fifty one patients with known indications for MMS were selected. They were operated under standard method of MMS, followed and evaluated for a 12 months period about recurrence, metastasis and cosmetic results. Results: 58 tumors from 51 patients were operated. 27.5 percent of patients were females and 72.5 percent were males (57.4± 13.4 year). Eight percent had more than one tumor. In 84 percent, MMS was the first treatment procedure. Anatomically lesions of scalp and face, trunk, and limbs constituted 92.5 percent, 1.9 percent, and 5.6 percent, respectively. Mean size of lesions was 16.9 mm (range: 4-70). The number of layers to clear the tumors was 1-5 (mean: 1.5). Histologically 81 percent of lesions were BCC, 9.4 percent SCC. Immediate reconstruction was performed in all patients as follows: 37 percent primary simple closure, 5.5 percent secondary healing, 50 percent skin flaps, 3.7 percent skin grafts and 3.7 percent a combination model. The percent of relative frequency of recurrence was 3.7 with no case of metastasis. Cosmetic results were excellent in 35 percent, good in 50 percent, intertmediate in 11.5 percent and poor in 3.5 percent of cases. Discussion: Despite paucity of patients" number, higher incidence of tumors in males of 50 or more, higher occurrence on scalp and face and most frequently occurring as BCC is prominently evident. One year recurrence rate of 3.7 percent is probably due to paucity of patients. Cosmetic results were mostly favorable (85 percent), and unfavorable results were due to secondary healing and large facial lesions repaired with flaps. For more valid evaluations, long term studies with greater number of patients is recommended.

Background: Nonmelanoma skin cancer rates are increasing worldwide. Mohs micrographic surgery and surgical excision (SE) are the two treatment methods for this type of cancer. The current paper aims at determining and comparing the cost-effectiveness of SE and Mohs micrographic surgery. Materials and Methods: The current study has a retrospective cohort design. A number of 630 patients suffering from nonmelanoma skin cancer who at some point of time during the years 2007–2014 referred to the Al-Zahra or Seyed Al-Shohada Hospitals in Isfahan. Patients were followed up for 4 years, and then the incremental cost-effectiveness ratio (ICER) of the two methods was calculated.Results: The average (minimum-maximum) cost of the SE and Mohs surgery methods in Iran was obtained as 18, 550, 170 (2335, 800–260, 898, 262) and 12, 236, 890 (6488, 340–41, 161, 700) Iranian Rial, respectively. Recurrence percentage was also reported as 7.9% and 8.7% for SE and Mohs micrographic surgery, respectively (P>0.05). The ICER of SE in comparison with Mohs surgery was calculated as 7891, 600 Iranian Rials per recurrence avoided.Conclusion: Mohs surgery is less expensive than SE, it seems like Mohs surgery is more affordable, however further studies in different populations of the country are needed.

Background: Around 80% of the all non-melanoma skin cancer cases suffer from basal cell carcinoma (BCC). Mohs surgery is one of the common method used for treatment in recent years. There are several treatment methods for primary BCC. One of these methods is Mohs micrographic surgery (Mohs surgery), which has become popular in recent years. Objectives: The aim of this study was to investigate 4-year recurrence and factors affecting the recurrence of BCC patients after Mohs surgery. Methods: This is a retrospective cohort study. The study population included all BCCs, who underwent Mohs surgery in Alzarha Hospital in Isfahan between 2007 and 2014, and were monitored for recurrence for 4 years. Cox regression analysis was used to determine factors affecting time recurrence. Results: The most and least frequent locations of this disease are nose (30. 3%) and body (0. 5%). The most common locations for recurrence are scalp (50%), nose (15%), and around the eyes (15%). The 4-year recurrence frequency of BCC after Mohs surgery was 0. 9%. Cox regression analysis relationship between determining factors affecting time recurrence was not significance. Conclusions: The causes of recurrence can include the less use of protective equipment in front of sunlight or low precision of doctors in the lesion surgery in locations of the body, arms, feet, head, neck, hands, legs or genital organs, and other parts of the body.

Sweat gland adenocarcinoma is a relatively uncommon malignancy. Clinical features are painless red or violet papules and nodules that can occasionally become ulcerated. The biological behavior is aggressive and metastatic sweat gland carcinoma spreads through the lymphatic. The treatment of choice is wide surgical excision with regional lymph node dissection. The portrayed ase was a 60-year-old female who presented with an ulcerative plaque on the scalp. Skin biopsy, radiologic examination, and immunohistochemistry (IHC) assay revealed adenocarcinoma of the sweat gland. Reconstructive surgery was performed immediately after Mohs surgery to repair the damaged site.